Background Fludarabine in combination with cyclophosphamide (FC) is the standard lymphodepletion regimen for CAR T-cell therapy (CAR T).A national fludarabine shortage in 2022 necessitated the exploration of alternative regimens with many centers employing single-agent bendamustine as lymphodepletion despite a lack of clinical safety and efficacy d
This paper presents a hybrid method to solve hard multiobjective problems.The proposed approach adopts an epsilon-constraint method which uses a shure ua874 Particle Swarm Optimizer to get points near of the true Pareto front.In this approach, only few points will be generated and then, new intermediate points will be calculated using an interpolat
Research and development of genetically engineered (GE) crops in Uganda was initiated in 2003 with the launch of a national agricultural biotechnology center at Kawanda in central Uganda.The country has now approved 17 field experiments for GE plants, which were first established in 2006 with the planting of a banana confined field trial that evalu
Despite its critical role in survival, many aspects of hematopoiesis remain unresolved.In the classical model of the hematopoietic program, quiescent hematopoietic stem cells (HSCs) sit at chromatic ire d2 the top of the hematopoietic hierarchy, with the ability to self-renew and differentiate as needed.HSCs give rise to more proliferative progenit